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Does adjunctive midazolam reduce recovery agitation after ketamine sedation for pediatric procedures? A randomized, double-blind, placebo-controlled trial

Sherwin TS, Green SM, Khan A, et al (2000). Annals of Emergency Medicine. Abstract Conclusions: “Recovery agitation is common but generally of very low magnitude after ketamine sedation in children in the ED. We observed a median physician rating of 5 mm on a 100-mm visual analog scale, a score that we believe to be […]

Adverse events associated with procedural sedation and analgesia in a pediatric emergency department: a comparison of common parenteral drugs

Roback MG, Wathen JE, Bajaj L, et al (2005). Academic Emergency Medicine. Abstract Conclusions: “Drug types used in pediatric PSA [pediatric sedation and analgesia] are associated with different adverse event profiles. Patients receiving ketamine with or without midazolam experienced fewer respiratory adverse events but more vomiting than the commonly used combination of midazolam and fentanyl. […]

Does midazolam alter the clinical effects of intravenous ketamine sedation in children? A double-blind, randomized, controlled, emergency department trial

Wathen JE, Roback MG, Mackenzie T, et al (2000). Annals of Emergency Medicine. Abstract Conclusions: “Ketamine and combined ketamine and midazolam provided equally effective sedation. The addition of midazolam did not alter the incidence of emergence phenomena. Vomiting occurred more frequently in the ketamine only group, whereas oxygen desaturation occurred more frequently in the ketamine-midazolam […]

A trial of metoclopramide vs sumatriptan for the emergency department treatment of migraines

Friedman BW, Corbo J, Lipton RB, et al (2005). Neurology. Abstract Conclusions: “When compared at 2 and 24 hours, aggressive (20 mg dosed up to four times) IV metoclopramide and 6 mg of subcutaneous sumatriptan relieved migraine headache pain comparably. Some secondary endpoints suggest that metoclopramide may be the preferable therapy for migraines presenting to […]